Mapping of noninvasion TnphoA mutations on the Escherichia coli O18:K1:H7 chromosome

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Mapping of noninvasion TnphoA mutations on the Escherichia coli O18:K1:H7 chromosome.

The most virulent newborn meningitis-associated Escherichia coli are of the serotype O18:K1:H7. We previously isolated a large number of E. coli O18:K1:H7 mutants resulting from transposon TnphoA mutagenesis that fail to invade brain microvascular endothelial cells. We have now determined Ic locations of 45 independent insertions. Twelve were localized to the 98 min region, containing a 120 kb ...

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ژورنال

عنوان ژورنال: FEMS Microbiology Letters

سال: 1996

ISSN: 0378-1097

DOI: 10.1016/0378-1097(96)00357-6